August 2010

Endocrine disruption induced by triorganotin (IV) compounds: Impacts in the reproductive and genetic function

      Organotin compounds, such as tributyltin (TBT) and triphenyltin (TPT), are typical environmental contaminants and suspected endocrine-disrupting chemicals because they cause irreversible sexual abnormality (masculinization) in female mollusks, called "imposex". However, it remains unclear whether organotin compounds also cause crucial toxicities in mammalian, including in human and...

Author(s): V. S. Delgado Filho, C. N. Mancini, I. V. Silva, D. F. Pedrosa, A. C. Destefani, V. Y. Samoto, C. M. Takiya and J. B. Graceli

August 2010

Effect of paternal age on aneuploidy rates in first trimester pregnancy loss

A retrospective cohort analysis of patients undergoing IVF cycles at an academic IVF center was performed to test the hypothesis that male age may influence aneuploidy rates in first trimester pregnancy losses. All patients had a first trimester pregnancy loss followed by evacuation of the pregnancy and karyotyping of the abortus. Couples undergoing anonymous donor oocyte ART cycles (n = 50) and 23 couples with female...

Author(s): Vitaly A. Kushnir, Richard T. Scott and John L. Frattarelli