Journal of
Medical Genetics and Genomics

  • Abbreviation: J. Med. Genet. Genomics
  • Language: English
  • ISSN: 2141-2278
  • DOI: 10.5897/JMGG
  • Start Year: 2009
  • Published Articles: 48

Full Length Research Paper

Endocrine disruption induced by triorganotin (IV) compounds: Impacts in the reproductive and genetic function

V. S. Delgado Filho1, C. N. Mancini1, I. V. Silva1, D. F. Pedrosa1,2, A. C. Destefani1, V. Y. Samoto3, C. M. Takiya3 and J. B. Graceli1*
1Ageing Cell Biology Laboratory, Department of Morphology, Health Sciences Center, Federal University of Espírito Santo, Vitória, ES, Brazil. 2Department of Pharmaceutical Sciences, Health Sciences Center, Federal University of Espírito Santo, Vitória, ES, Brazil. 3Institute of Biomedical Sciences, Federal University of Rio de Janeiro, RJ, Brazil.
Email: [email protected], [email protected]

  •  Accepted: 09 June 2010
  •  Published: 31 August 2010


      Organotin compounds, such as tributyltin (TBT) and triphenyltin (TPT), are typical environmental contaminants and suspected endocrine-disrupting chemicals because they cause irreversible sexual abnormality (masculinization) in female mollusks, called "imposex". However, it remains unclear whether organotin compounds also cause crucial toxicities in mammalian, including in human and rodents, in their sexual development and reproductive functions. Moreover, these compounds can act as potential competitive inhibitors of aromatase enzyme or others steroidogenic enzymes and recently, it was identified as agonists for retinoid X receptor (RXR) and peroxisome proliferator-activated receptor (PPAR)γ, which are members of the nuclear receptor superfamily. Gene expression of human aromatase is regulated by the activation of PPARγ and/or RXR. In this review, the authors provide a discussion of the cellular, biochemical, and molecular mechanisms by which organotin compounds may cause adverse effects in the modulated genes involved in reproductive function.


Key words: Organotin, endocrine disruptor, aromatase, mammalian reproductive function.