Abstract

The study is aimed examining HLA-DQA1 and HLA-DQB1 genotyping in individuals (patients and controls) with family history of gastritis. This study was carried out in College of Medicine, University of Basrah. HLA-DQA1 and HLA-DQB1 genotyping was done in College of Medicine, University of Manitoba, Winnpeg, Canada during the period from 17 April, 2009 to 15 July, 2010. A total of 100 patients [41 males and 59 females and a total of 30 controls (18 males and 12 females)] were included in this study. A significant decreased frequency of DQA1*0201 allele was found in individuals (patient + controls) with family history of gastritis with a strong association (odds ratio = 4.57), as compared with individuals without family history of gastritis. Significant increased alleles frequencies of DQA1*0402 and DQB1*0402 were found in individuals with family history of gastritis, but with weak association (odds ratios, 0.16 and 0.20, respectively), as compared with individuals without family history of gastritis.   

Key words: HLA-DQA1 and HLA-DQB1 genotyping, gastritis, family history.