Introduction: Prostate cancer is an androgen dependent cancer. Globally, it is the second most common cancer. Prostate cancer onset is mostly asymptomatic, posing a challenge for its early detection. This cohort study describes the clinical characteristics of prostate cancer patients from Kampala Cancer Registry, Uganda. Materials and Methods: This was a retrospective cohort study involving 136 patients who were followed up for at least 3 years after being registered at Kampala Cancer Registry (KCR), a population-based cancer registry. This cancer registry is located in the department of pathology, Makerere College of Health Sciences. Tissue blocks of the patients were retrieved from the repository of the department and sectioned and reported by two independent pathologists in a blind manner. Data were analysed using STATA version 12.0 programme. Association of the variables was computed using Chi-Square and logistic regression where applicable at 95% confidence and a two-tailed PË‚0.05 was regarded statistically significant. Results: The most common clinical feature in this study was bladder outlet obstruction which constituted 33.8% (n = 46) and the majority of the patients, 67.7% (n = 92) had advanced clinical stages (III and IV). Age and clinical stage of the patients were statistically significantly associated with the presence of extra-prostatic extension in the patients; P = 0.024 and 0.001 respectively. Conclusions: Patients with prostate cancer at KCR have very high Prostate Specific Antigen at diagnosis and advanced clinical stage. Age of the patient and clinical stage were the predictors of extra-prostatic extension in this study.

Keywords: Prostate cancer; Clinical features; Extraprostatic extension.