June 2019

In vitro evaluation of fruit extracts of Annona stenophylla diels and Flacourtia indica for incorporation into formulations for management of cancer

There are many reports which show a positive relationship between free radical damage and diseases such as cancer. Free radicals are formed when humans are exposed to ionizing radiation or during oxidation process in human beings can damage tissues and may potentially lead to development of cancers. Since radiation may be used in the management of cancer, there is need for the development of a radioprotective herbal...

Author(s): Cosmas Josiah Musewu and Rudo Fiona Mapanga  

June 2019

Chemical fingerprint of Bacopa monnieri L. and Rosmarinus officinalis L. and their neuroprotective activity against Alzheimer's disease in rat model’s putative modulation via cholinergic and monoaminergic pathways

Alzheimer’s disease is characterized by progressive degeneration of cortical and hippocampal neurons. This study aims to characterize the metabolic profiles of the hydro-ethanolic extracts of Bacopa monnieri L. (BM) and Rosmarinus officinalis L. (RO) cultivated in Egypt via UPLC–ESI/MS analyses and reveal their possible mechanism of the prophylactic effect(s) on neuro-degeneration in rat model of...

Author(s): Nermien E. Waly, Nora M. Aborehab and Mahitab H. El Bishbishy  

June 2019

Evaluation of the in vivo antiplasmodial activity of ethanol leaf extract and fractions of Jatropha gossypifolia in Plasmodium berghei infected mice

The study evaluates the in vivo antiplasmodial activity of ethanol leaf extract and fractions of Jatropha gossypifolia in Plasmodium berghei infected mice. Phytochemical, physicochemical analyses, median lethal dose (LD50), effects on biochemical parameter were evaluated and the schizonticidal effects during early and established infections were investigated. The extract (50-200 mg/kg) was screened for antimalarial...

Author(s): Onyegbule F. A., Bruce S. O., Onyekwe O. N., Onyealisi O. L. and Okoye P. C.