May 2016

Phytochemical and pharmacological studies of Citharexylum quadrangulare Jacq. leaves

Chromatographic investigation of the Citharexylum quadrangulare leaves led to isolation of nine compounds viz., stigmasterol (1), β-sitosterol (2), oleanolic acid (3), duranterectoside B (4), durantoside I (5), cirsimaritin 4'-O-β-D-glucopyranoside (6), 5-deoxypulchelloside (7), lamiide (8) and cirsimaritin 4'-O-β-D-glucopyranoside 4"-sodium sulphate (9). The compounds (1, 3 and 4) were...

Author(s): Marwa Hassan Hussaen Mohammed, Ashraf Nageeb El-Sayed Hamed, Hany Ezzat Khalil and Mohamed Salah Kamel

May 2016

Inhibitory activity of fractions of Senna nigricans toward protein tyrosine phosphatase 1B and dipeptidyl peptidase IV

Protein tyrosine phosphatase (PTP) 1B and dipeptidyl peptidase (DPP) IV are important in down regulation and secretion of insulin, respectively. While PTP 1B regulates insulin binding to its receptor, DPP IV hydrolyses incretin, which is an important regulator of postprandial insulin secretion. The study evaluated the in vitro inhibitory effect of different fractions of Senna nigricans against PTP IB and DPP IV and the...

Author(s): Yusuf Saidu, Suleiman Alhaji Muhammad, Lawal Suleiman Bilbis and Babangida Muhammad Sani