April 2019

Isolation and identification of compounds with dioxin-induced AhR transformation inhibitory activity from the leaves of Mallotus japonicus (Thunb.) Muell. Arg.

The solvent extracts of 368 plant parts from 191 different species cultivated in Tsukuba (Ibaraki Prefecture, Japan) were previously screened for aryl hydrocarbon receptor (AhR) transformation inhibitory activity. It was observed that the leaf extract of Mallotus japonicus had strong activity. To clarify the antidioxin phytochemical, a 70% acetone extraction from the leaves was fractionated with three kinds of solvent...

Author(s): Keizo Hosokawa, Atsuyuki Hishida, Shin Nishiumi, Eri Fukushi, Jun Kawabata and Hitoshi Ashida