Journal of
Metabolomics and Systems Biology

  • Abbreviation: J. Metabolomics Syst. Biol.
  • Language: English
  • ISSN: 2805-4210
  • DOI: 10.5897/JMSB
  • Start Year: 2010
  • Published Articles: 9

Review

Taurine is a future biomolecule for potential health benefits: A review

Rajeshwar Nath Srivastava
  • Rajeshwar Nath Srivastava
  • Department of Orthopaedic Surgery, King George’s Medical University, Nabiullah Road, Daliganj, Lucknow, Uttar Pradesh, Pin code-226018 India.
  • Google Scholar
Zeenat Ara
  • Zeenat Ara
  • Department of Orthopaedic Surgery, King George’s Medical University, Nabiullah Road, Daliganj, Lucknow, Uttar Pradesh, Pin code-226018 India.
  • Google Scholar
Shah Waliullah
  • Shah Waliullah
  • Department of Orthopaedic Surgery, King George’s Medical University, Nabiullah Road, Daliganj, Lucknow, Uttar Pradesh, Pin code-226018 India.
  • Google Scholar
Alka Singh
  • Alka Singh
  • Department of Orthopaedic Surgery, King George’s Medical University, Nabiullah Road, Daliganj, Lucknow, Uttar Pradesh, Pin code-226018 India.
  • Google Scholar
Saloni Raj
  • Saloni Raj
  • Department of Orthopaedic Surgery, King George’s Medical University, Nabiullah Road, Daliganj, Lucknow, Uttar Pradesh, Pin code-226018 India.
  • Google Scholar
Abbas Ali Mahdi
  • Abbas Ali Mahdi
  • Department of Biochemistry, King George’s Medical University, Shahmina Road, Chowk, Lucknow, Uttar Pradesh, Pin code-226003, India.
  • Google Scholar
Ravindra Kumar Garg
  • Ravindra Kumar Garg
  • Department of Neurology, King George’s Medical University, Shahmina Road, Chowk, Lucknow, Uttar Pradesh, Pin code-226003, India.
  • Google Scholar
Raja Roy
  • Raja Roy
  • Centre of Biomedical Research, Formerly Centre of Biomedical Magnetic Resonance (CBMR), Sanjay Gandhi Postgraduate Institute of Medical Sciences Campus, Rae Bareli Road, Lucknow, Uttar Pradesh, Pin code-226014, India.
  • Google Scholar


  •  Received: 06 October 2021
  •  Accepted: 09 February 2022
  •  Published: 30 September 2022

References

Abbasian N, Ghaderi-Najafabadi M, Watson E, Brown J, Bursnall D, Pawluczyk I, Seymour AM, Bevington A (2021). Hepatic cysteine sulphinic acid decarboxylase depletion and defective taurine metabolism in a rat partial nephrectomy model of chronic kidney disease. BMC Nephrology 22(1):1-2.
Crossref

 

Arrieta F, Balsa JA, de la Puerta C, Botella JI, Zamarrón I, Elías E, Del Río JI, Alonso P, Candela Á, Blanco?Colio LM, Egido J(2014). Phase IV prospective clinical study to evaluate the effect of taurine on liver function in postsurgical adult patients requiring parenteral nutrition. Nutrition in Clinical Practice 29(5):672-680.
Crossref

 
 

Baliou S, Adamaki M, Ioannou P, Pappa A, Panayiotidis MI, Spandidos DA, Christodoulou I, Kyriakopoulos AM, Zoumpourlis V (2021). Protective role of taurine against oxidative stress. Molecular Medicine Reports 24(2):1-9.
Crossref

 
 

Bellentani S, Pecorari M, Cordoma P, Marchegiano P, Manenti F, Bosisio E, De Fabiani E, Galli G (1987). Taurine increases bile acid pool size and reduces bile saturation index in the hamster. Journal of Lipid Research 28(9):1021-1027.
Crossref

 
 

Bhat MY, Singh LR, Dar TA (2020). Taurine induces an ordered but functionally inactive conformation in intrinsically Disordered casein proteins. Scientific Reports 10(1):1-1.
Crossref

 
 

Bian Y, Zhang M, Wang K (2018). Taurine protects against knee osteoarthritis development in experimental rat models. The Knee 25(3):374-380.
Crossref

 
 

Birdsall TC (1998). Therapeutic applications of taurine. Alternative medicine review: a journal of clinical therapeutic 3(2):128-136.

 
 

Bkaily G, Jazzar A, Normand A, Simon Y, Al-Khoury J, Jacques D (2020). Taurine and cardiac disease: state of the art and perspectives. Canadian Journal of Physiology and Pharmacology 98(2):67-73.
Crossref

 
 

Bouckenooghe T, Remacle C, Reusens B (2006). Is taurine a functional nutrient? Current Opinion in Clinical Nutrition and Metabolic Care 9(6):728-33.
Crossref

 
 

Chatterji T, Singh S, Sen M, Singh AK, Agarwal GR, Singh DK, Srivastava JK, Singh A, Srivastava RN, Roy R (2017). Proton NMR metabolic profiling of CSF reveals distinct differentiation of meningitis from negative controls. Clinica Chimica Acta 469:42-52.
Crossref

 
 

Chen C, Yang Q, Ma X (2020). Synergistic effect of ascorbic acid and taurine in the treatment of a spinal cord injury-induced model in rats. 3 Biotech 10(2):1-8.
Crossref

 
 

Chen W, Matuda K, Nishimura N, Yokogoshi H (2004). The effect of taurine on cholesterol degradation in mice fed a high-cholesterol diet. Life Sciences 74(15):1889-1898.
Crossref

 
 

Chen Y, Liu CP, Xu KF, Mao XD, Lu YB, Fang L, Yang JW, Liu C (2008). Effect of tau-rine-conjugated ursodeoxycholic acid on endoplasmic reticulum stress and apoptosis induced by advanced glycation end products in cultured mouse podocytes. American Journal of Nephrology 28(6):1014-1022.
Crossref

 
 

Chesney RW, Gusowski N, Dabbagh S (1985). Renal cortex taurine content regulates renal adaptive response to altered dietary intake of sulfur amino acids. The Journal of Clinical Investigation 76(6):2213-2221.
Crossref

 
 

Chesney RW, Han X, Patters AB (2010). Taurine and the renal system. Journal of Biomedical Science 17(1):1-0.
Crossref

 
 

Chung MC, Malatesta P, Bosquesi PL, Yamasaki PR, Santos JL, Vizioli EO (2012). Advances in drug design based on the amino acid approach: Taurine analogues for the treatment of CNS diseases. Pharmaceuticals 5(10):1128-1146.
Crossref

 
 

Chupel MU, Minuzzi LG, Furtado GE, Santos ML, Ferreira JP, Filaire E, Teixeira AM (2021). Taurine supplementation reduces myeloperoxidase and matrix-metalloproteinase-9 levels and improves the effects of exercise in cognition and physical fitness in older women. Amino Acids 53(3):333-345.
Crossref

 
 

De Luca A, Pierno S, Camerino DC (2015). Taurine: the appeal of a safe amino acid for skeletal muscle disorders. Journal of translational medicine 13(1):1-8.
Crossref

 
 

De Luca G, Calpona PR, Caponetti A, Romano G, Di Benedetto A, Cucinotta D, Di Giorgio RM (2001). Taurine and osmoregulation: platelet taurine content, uptake, and release in type 2 diabetic patients. Metabolism-Clinical and Experimental 50(1):60-64.
Crossref

 
 

Engelborghs, S., Marescau, B., and De Deyn, P. P. (2003). Amino acids and biogenic amines in cerebrospinal fluid of patients with Parkinson's disease. Neurochemical Research. 28(8):1145-1150. 
Crossref

 
 

Franconi F, Bennardini F, Mattana A, Miceli M, Ciuti M, Mian M, Gironi A, Anichini R, Seghieri G (1995). Plasma and platelet taurine are reduced in subjects with insulin-dependent diabetes mellitus: effects of taurine supplementation. The American Journal of Clinical Nutrition 61(5):1115-1119.
Crossref

 
 

Franscescon F, Müller TE, Bertoncello KT, Rosemberg DB (2020). Neuroprotective role of taurine on MK-801-induced memory impairment and hyperlocomotion in zebrafish. Neurochemistry international 135:104710.
Crossref

 
 

Gaull GE (1986). Taurine as a conditionally essential nutrient in man. Journal of the American College of Nutrition 5(2):121-125.
Crossref

 
 

Gaull GE (1989). Taurine in pediatric nutrition: review and update. Pediatrics 83(3):433-442.
Crossref

 
 

Geggel HS, Ament ME, Heckenlively JR, Martin DA, Kopple JD (1985). Nutritional requirement for taurine in patients receiving long-term parenteral nutrition. New England Journal of Medicine 312(3):142-146.
Crossref

 
 

Ghandforoush-Sattari M, Mashayekhi S, Krishna CV, Thompson JP, Routledge PA (2010). Pharmacokinetics of oral taurine in healthy volunteers. Journal of Amino Acids 2010.
Crossref

 
 

Ginguay A, De Bandt JP, Cynober L (2016). Indications and contraindications for infusing specific amino acids (leucine, glutamine, arginine, citrulline, and taurine) in critical illness. Current Opinion in Clinical Nutrition and Metabolic Care 19(2):161-169.
Crossref

 
 

Gupta RC, Seki Y, Yosida J (2006). Role of taurine in spinal cord injury. Current neurovascular research 3(3):225-235.
Crossref

 
 

Gupta, RC, Kim SJ (2003). Role of taurine in organ's dysfunction and in their alleviation. Critical Care and Shock 6:191-197.

 
 

Gupta, RC, Win, T, Bittner S (2005). Taurine analogs a new class of therapeutic Ret-rospect and prospect. Current medicinal chemistry 12(17):2021-2039.
Crossref

 
 

Hansen SH (2001). The role of taurine in diabetes and the development of diabetic complications. Diabetes/Metabolism Research and Reviews 17(5):330-346.
Crossref

 
 

Hernández-Benítez R, Ramos-Mandujano G, Pasantes-Morales H (2012). Taurine stimulates proliferation and promotes neurogenesis of mouse adult cultured neural stem/progenitor cells. Stem Cell Research 9(1):24-34.
Crossref

 
 

Hou X, Wang Z, Ding F, He Y, Wang P, Liu X, Xu F, Wang J, Yang Y (2019). Taurine transporter regulates adipogenic differentiation of human adipose-derived stem cells through affecting Wnt/β-catenin signaling pathway. International Journal of Biological Sciences 15(5):1104.
Crossref

 
 

Huxtable RJ (1992). Physiological actions of taurine. Physiological reviews 72(1):101-163.
Crossref

 
 

Imae M, Asano T, Murakami S (2014). Potential role of taurine in the prevention of diabetes and metabolic syndrome. Amino Acids 46(1):81-88.
Crossref

 
 

Ito T, Kimura Y, Uozumi Y, Takai M, Muraoka S, Matsuda T, Ueki K, Yoshiyama M, Ikawa M, Okabe M, Schaffer SW (2008). Taurine depletion caused by knocking out the taurine transporter gene leads to cardiomyopathy with cardiac atrophy. Journal of Molecular and Cellular Cardiology 44(5):927-937.
Crossref

 
 

Ito T, Yoshikawa N, Inui T, Miyazaki N, Schaffer SW, Azuma J (2014). Tissue depletion of taurine accelerates skeletal muscle senescence and leads to early death in mice. PloS One 9(9):e107409.
Crossref

 
 

Ito T, Yoshikawa N, Ito H, Schaffer SW (2015). Impact of taurine depletion on glucose control and insulin secretion in mice. Journal of Pharmacological Sciences 129(1):59-64.
Crossref

 
 

Jacobsen JG, Smith LH (1968). Biochemistry and physiology of taurine and taurine derivatives. Physiological Reviews 48(2):424-511.
Crossref

 
 

Jangra A, Rajput P, Dwivedi DK, Lahkar M (2020). Amelioration of repeated restraint stress-induced behavioral deficits and hippocampal anomalies with taurine treatment in mice. Neurochemical Research 45(4):731-740.
Crossref

 
 

Kawasaki A, Ono A, Mizuta S, Kamiya M, Takenaga T, Murakami S (2017). The taurine content of Japanese seaweed. In Taurine 10 (pp. 1105-1112). Springer, Dordrecht.
Crossref

 
 

Kurtz JA, VanDusseldorp TA, Doyle JA, Otis JS (2021). Taurine in sports and exercise. Journal of the International Society of Sports Nutrition 18(1):1-20.
Crossref

 
 

La Bella V, Piccoli F (2000). Differential effect of β-N-oxalylamino-l-alanine, the Lathyrus sativus neurotoxin, and (±)-α-amino-3-hydroxy-5-methylisoxazole-4-propionate on the excitatory amino acid and taurine levels in the brain of freely moving rats. Neurochemistry international 36(6):523-530.
Crossref

 
 

Lam NV, Chen W, Suruga K, Nishimura N, Goda T, Yokogoshi H (2006). Enhancing effect of taurine on CYP7A1 mRNA expression in Hep G2 cells. Amino Acids 30(1):43-48.
Crossref

 
 

Liu J, Liu L, Chen H (2011). Antenatal taurine supplementation for improving brain ultrastructure in fetal rats with intrauterine growth restriction. Neuroscience 181:265-270.
Crossref

 
 

Lobo MV, Alonso FJ, Latorre A, del Río RM (2001). Taurine levels and localisation in the stratified squamous epithelia. Histochemistry and Cell Biology 115(4):341-347.
Crossref

 
 

Maturo J, Kulakowski EC (1988). Taurine binding to the purified insulin receptor. Biochemical Pharmacology 37(19):3755-3760.
Crossref

 
 

McCarty MF (2017). Supplementation with phycocyanobilin, citrulline, taurine, and Supranutritional doses of folic acid and Biotin-Potential for preventing or slowing the progression of diabetic complications. InHealthcare 5(1):15. Multidisciplinary Digital Publishing Institute.
Crossref

 
 

Menzie J, Prentice H, Wu JY (2013). Neuroprotective mechanisms of taurine against ischemic stroke. Brain Sciences 3(2):877-907.
Crossref

 
 

Merheb M, Daher RT, Nasrallah M, Sabra R, Ziyadeh FN, Barada K (2007). Taurine intestinal absorption and renal excretion test in diabetic patients: a pilot study. Diabetes Care 30(10):2652-2654.
Crossref

 
 

Miyata M, Matsushita K, Shindo R, Shimokawa Y, Sugiura Y, Yamashita M (2020). Selenoneine ameliorates hepatocellular injury and hepatic steatosis in a mouse model of NAFLD. Nutrients 12(6):1898.
Crossref

 
 

Miyata M, Tanaka T, Takahashi K, Funaki A, Sugiura Y (2021). Cholesterol-lowering effects of taurine through the reduction of ileal FXR signaling due to the alteration of ileal bile acid composition. Amino Acids 53(10):1523-1532.
Crossref

 
 

Murakami S, Sakurai T, Tomoike H, Sakono M, Nasu T, Fukuda N (2010). Prevention of hypercholesterolemia and atherosclerosis in the hyperlipidemia-and atherosclerosis-prone Japanese (LAP) quail by taurine supplementation. Amino Acids 38(1):271-278.
Crossref

 
 

Murakami S, Yamagishi I, Asami Y, Ohta Y, Toda Y, Nara Y, Yamori Y (1996). Hypolipidemic effect of taurine in stroke-prone spontaneously hypertensive rats. Pharmacology 52(5):303-313.
Crossref

 
 

Miyazaki T, Matsuzaki Y (2014). Taurine and liver diseases: a focus on the heterogeneous protective properties of taurine. Amino acids 46(1):101-110.
Crossref

 
 

Nakajima Y, Osuka K, Seki Y, Gupta RC, Hara M, Takayasu M, Wakabayashi T (2010). Taurine reduces inflammatory responses after spinal cord injury. Journal of neurotrauma 27(2):403-410.
Crossref

 
 

Niu X, Zheng S, Liu H, Li S (2018). Protective effects of taurine against inflammation, apoptosis, and oxidative stress in brain injury. Molecular Medicine Reports 18(5):4516-4522.
Crossref

 
 

Ohsawa Y, Hagiwara H, Nishimatsu SI, Hirakawa A, Kamimura N, Ohtsubo H, Fukai Y, Murakami T, Koga Y, Goto YI, Ohta S (2019). Taurine supplementation for prevention of stroke-like episodes in MELAS: a multicentre, open-label, 52-week phase III trial. Journal of Neurology, Neurosurgery and Psychiatry 90(5):529-536.
Crossref

 
 

Ommati MM, Heidari R, Ghanbarinejad V, Abdoli N, Niknahad H (2019). Taurine treatment provides neuroprotection in a mouse model of manganism. Biological trace element research 190(2):384-395.
Crossref

 
 

Page LK, Jeffries O, Waldron M (2019). Acute taurine supplementation enhances thermoregulation and endurance cycling performance in the heat. European Journal of Sport Science 19(8):1101-1109.
Crossref

 
 

Park E, Park SY, Dobkin C, Schuller-Levis G (2014). Development of a novel cysteine sulfinic acid decarboxylase knockout mouse: dietary taurine reduces neonatal mortality. Journal of Amino Acids 12 p.
Crossref

 
 

Pasantes-Morales H (2017). Taurine homeostasis and volume control. Glial Amino Acid Transporters pp. 33-53.
Crossref

 
 

Petty MA, Kintz J, DiFrancesco GF (1990). The effects of taurine on atherosclerosis development in cholesterol-fed rabbits. European Journal of Pharmacology 180(1):119-127.
Crossref

 
 

Prentice H, Modi JP, Wu JY (2015). Mechanisms of neuronal protection against excitotoxicity, endoplasmic reticulum stress, and mitochondrial dysfunction in stroke and neurodegenerative diseases. Oxidative Medicine and Cellular Longevity.
Crossref

 
 

Redmond HP, Stapleton PP, Neary P, Bouchier-Hayes D (1998). Immunonutrition: the role of taurine. Nutrition 14(7-8):599-604.
Crossref

 
 

Rikimaru M, Ohsawa Y, Wolf AM, Nishimaki K, Ichimiya H, Kamimura N, Nishi-matsu SI, Ohta S, Sunada Y (2012). Taurine ameliorates impaired the mitochondrial function and prevents stroke-like episodes in patients with MELAS. Internal Medicine 51(24):3351-3367.
Crossref

 
 

Ripps H, Shen W (2012). taurine: a "very essential" amino acid. Molecular Vision 18:2673.

 
 

Rockel N, Esser C, Grether-Beck S, Warskulat U, Flögel U, Schwarz A, Schwarz T, Yarosh D, Häussinger D, Krutmann J (2007). The osmolyte taurine protects against ultraviolet B radiation-induced immunosuppression. The Journal of Immunology 179(6):3604-3612.
Crossref

 
 

Rosa FT, Freitas EC, Deminice R, Jordao AA, Marchini JS (2014). Oxidative stress and inflammation in obesity after taurine supplementation: a double-blind, placebo-controlled study. European Journal of Nutrition 53(3):823-830.
Crossref

 
 

Sagara M, Murakami S, Mizushima S, Liu L, Mori M, Ikeda K, Nara Y, Yamori Y (2015). Taurine in 24-h urine samples is inversely related to cardiovascular risks of middle aged subjects in 50 populations of the world. In Taurine 9: 623-636. Springer, Cham.
Crossref

 
 

Sanghi D, Avasthi S, Srivastava RN, Singh A (2009). "Nutritional Factors and Osteoarthritis- A Review Article". Internet Journal of Medical Update 4(1).
Crossref

 
 

Sanghi D, Mishra A, Sharma AC, Singh A, Natu SM, Agarwal S, Srivastava RN (2013). Does vitamin D improve osteoarthritis of the knee: a randomized controlled pilot trial. Clinical Orthopaedics and Related Research® 471(11):3556-62.
Crossref

 
 

Schaffer S, Kim HW (2018). Effects and mechanisms of taurine as a therapeutic agent. Biomolecules and Therapeutics 26(3):225.
Crossref

 
 

Sergeeva OA, Fleischer W, Chepkova AN, Warskulat U, Häussinger D, Siebler M, Haas HL (2007). GABAA?receptor modification in taurine transporter knockout mice causes striatal disinhibition. The Journal of Physiology 585(2):539-48.
Crossref

 
 

Shao A, Hathcock JN (2008). Risk assessment for the amino acids taurine, L-glutamine and L-arginine. Regulatory Toxicology and Pharmacology 50(3):376-99.
Crossref

 
 

Shivaraj MC, Marcy G, Low G, Ryu JR, Zhao X, Rosales FJ, Goh EL (2012). Taurine induces proliferation of neural stem cells and synapse development in the developing mouse brain.
Crossref

 
 

Siefken W, Carstensen S, Springmann G, Wittern KP, Wenck H, Stäb F, Sauermann G, Schreiner V, Doering T, Janeke G, Bleck O (2003). Role of taurine accumulation in keratinocyte hydration. Journal of investigative dermatology 121(2):354-361.
Crossref

 
 

Singh A, Srivastava RN, Agrahari A, Singh S, Raj S, Chatterji T, Mahdi AA, Garg RK, Roy R (2018). Proton NMR based serum metabolic profile correlates with the neurological recovery in treated acute spinal cord injury (ASCI) subjects: A pilot study. Clinica Chimica Acta 480:150-160.
Crossref

 
 

Singh A, Srivastava RN, Chatterji T, Singh S, Raj L, Mahdi AA, Garg RK, Roy R (2020). 1H NMR urine metabolomics is an effective prognostic indicator in acute spinal cord injury (ASCI): A prospective case-control study. Journal of Metabolomics and Systems Biology 4(1):1-21.

 
 

Sobrido-Cameán D, Fernández-López B, Pereiro N, Lafuente A, Rodicio MC, Barreiro-Iglesias A (2020). Taurine promotes axonal regeneration after a complete spinal cord injury in lampreys. Journal of neurotrauma 37(6):899-903.
Crossref

 
 

Son M, Kim HK, Kim WB, Yang J, Kim BK (1996). Protective effect of taurine on indomethacin-induced gastric mucosal injury. Advances in Experimental Medicine and Biology 403:147-155.
Crossref

 
 

Son M, Kim HK, Kim WB, Yang J, Kim BK (1996). Protective effect of taurine on indomethacin-induced gastric mucosal injury. Archives of Pharmacal Research 19(2):85-90.
Crossref

 
 

Srivastava RN, Singh A, Garg RK, Agarwal A, Raj S (2015). Epidemiology of traumatic spinal cord injury: A SAARC perspective. International Journal of Biochemistry and Molecular Biology 3:9-22.

 
 

Stapleton PP, Mahon TM, Nowlan P, Bloomfield FJ (1994). Effects of in-vivo administration of taurine and HEPES on the inflammatory response in rats. Journal of pharmacy and pharmacology 46(9):745-50.
Crossref

 
 

Sturman JA, Hayes KC (1980). The biology of taurine in nutrition and development. InAdvances in nutritional research (pp. 231-299). Springer, Boston, MA.
Crossref

 
 

Su Y, Fan W, Ma Z, Wen X, Wang W, Wu Q, Huang H (2014). Taurine improves functional and histological outcomes and reduces inflammation in traumatic brain injury. Neuroscience 266:56-65.
Crossref

 
 

Sun Q, Hu H, Wang W, Jin H, Feng G, Jia N (2014). Taurine attenuates amyloid β 1-42-induced mitochondrial dysfunction by activating of SIRT1 in SK-N-SH cells. Biochemical and Biophysical Research Communications 447(3):485-9.
Crossref

 
 

Sun M, Zhao Y, Gu Y, Zhang Y (2015). Protective effects of taurine against closed head in-jury in rats. Journal of Neurotrauma. 32(1):66-74.
Crossref

 
 

Vahdat M, Hosseini SA, Soltani F, Cheraghian B, Namjoonia M (2021). The effects of Taurine supplementation on inflammatory markers and clinical outcomes in patients with traumatic brain injury: a double-blind randomized controlled trial. Nutrition Journal 20(1):1-9.
Crossref

 
 

Vidot H, Cvejic E, Carey S, Strasser SI, McCaughan GW, Allman?Farinelli M, Shackel NA (2018). Randomised clinical trial: oral taurine supplementation versus placebo reduces muscle cramps in patients with chronic liver disease. Alimentary pharmacology & therapeutics 48(7):704-12.
Crossref

 
 

Waldmann-Laue MA, Forster TH (2006). Taurine improves epidermal barrier properties stressed by surfactantsA role for osmolytes in barrier homeostasis. Journal of Cosmetic Science 57:1-0.

 
 

Waldron M, Patterson SD, Tallent J, Jeffries O (2018). The effects of oral taurine on resting blood pressure in humans: a meta-analysis. Current Hypertension Reports 20(9):1-8.
Crossref

 
 

Wang Q, Fan W, Cai Y, Wu Q, Mo L, Huang Z, Huang H (2016). Protective effects of taurine in traumatic brain injury via mitochondria and cerebral blood flow. Amino Acids 48(9):2169-2177.
Crossref

 
 

Warskulat U, Borsch E, Reinehr R, Heller?Stilb B, Mönnighoff I, Buchczyk D, Donner M, Flögel U, Kappert G, Soboll S, Beer S (2006). Chronic liver disease is triggered by taurine transporter knockout in the mouse. The FASEB Journal 20(3):574-576.
Crossref

 
 

Lotocki G, de Rivero Vaccari JP, Perez ER, Sanchez-Molano J, Furones-Alonso O, Bramlett HM, Dietrich WD (2009). Alterations in blood-brain barrier permeability to large and small molecules and leukocyte accumulation after traumatic brain injury: effects of post-traumatic hypothermia. Journal of Neurotrauma 26(7):1123-1134.
Crossref

 
 

Wójcik OP, Koenig KL, Zeleniuch-Jacquotte A, Costa M, Chen Y (2010). The potential protective effects of taurine on coronary heart disease. Atherosclerosis 208(1):19-25.
Crossref

 
 

Wright CE, Tallan HH, Lin YY, Gaull GE (1986). Taurine: biological update. Annual Review of Biochemistry 55(1):427-453.
Crossref

 
 

Wu G (2020). Important roles of dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline in human nutrition and health. Amino Acids 52(3):329-60.
Crossref

 
 

Wu GF, Ren S, Tang RY, Xu C, Zhou JQ, Lin SM, Feng Y, Yang QH, Hu JM, Yang JC (2017). Antidepressant effect of taurine in chronic unpredictable mild stress-induced de-pressive rats. Scientific reports 7(1):1-4.
Crossref

 
 

Xu YJ, Arneja AS, Tappia PS, Dhalla NS (2008). The potential health benefits of taurine in cardiovascular disease. Experimental and Clinical Cardiology 13(2):57.

 
 

Yamori Y, Taguchi T, Mori H, Mori M (2010). Low cardiovascular risks in the middle aged males and females excreting greater 24-hour urinary taurine and magnesium in 41 WHO-CARDIAC study populations in the world. Journal of Biomedical Science 17(1):1-5.
Crossref

 
 

Yokogoshi H, Mochizuki H, Nanami K, Hida Y, Miyachi F, Oda H (1999). Dietary taurine enhances cholesterol degradation and reduces serum and liver cholesterol concentrations in rats fed a high-cholesterol diet. The Journal of Nutrition 129(9):1705-1712.
Crossref

 
 

Yoshimura T, Inokuchi Y, Mutou C, Sakurai T, Nagahama T, Murakami S (2021). Age-related decline in the taurine content of the skin in rodents. Amino Acids 53(3):429-434.
Crossref

 
 

Zeng DS, Gao ZH, Huang XL, Zhao JH, Huang GQ, Duo L (2012). Effect of taurine on lipid metabolism of broilers. Journal of Applied Animal Research 40(2):86-89.
Crossref

 
 

Zhang L, Wang Y, Sohail T, Kang Y, Niu H, Sun X, Ji D, Li Y (2021). Effects of Taurine on Sperm Quality during Room Temperature Storage in Hu Sheep. Animals 11(9):2725.
Crossref

 
 

Zhang M, Shi X, Luo M, Lan Q, Ullah H, Zhang C, Li S, Chen X, Wang Y, Piao F (2021). Taurine ameliorates axonal damage in sciatic nerve of diabetic rats and high glucose exposed DRG neuron by PI3K/Akt/mTOR-dependent pathway. Amino Acids 53(3):395-406.
Crossref

 
 

Zhao H, Qu J, Li Q, Cui M, Wang J, Zhang K, Liu X, Feng H, Chen Y (2018). Taurine supplementation reduces neuroinflammation and protects against white matter injury after intracerebral hemorrhage in rats. Amino Acids 50(3):439-51.
Crossref