Transitioning from a life-threatening infection resulting in acute illness to a long-term manageable condition implies that HIV management requires collaboration between the primary care clinicians and rehabilitation teams. Being an effective, safe, and beneficial health strategy, physical activity has been recommended in HIV management. Despite its numerous benefits, there is still a low prevalence of physical activity in sub-Saharan Africa as it has been reported that people living with HIV-related disability do not engage in sufficient physical activity. This study seeks to explore the extent and nature of HIV-related disability in Nigeria, its impact on their quality of life and how certain factors may influence participation in physical activity. The goal is to develop a context-specific physical activity program to address rehabilitation needs. Employing a mixed-methods approach in three phases, the study will conduct a cross-sectional survey, one-on-one interviews, and a scoping review in the first phase. Data from phase one will be integrated using a clinical reasoning approach. The second phase involves a modified Delphi study to evaluate the developed physical activity program, while the third phase assesses program feasibility. The study population includes individuals aged 18 and above living with HIV/AIDS in Lagos state, Nigeria. The findings will contribute valuable insights into the extent of HIV-related disability, its impact, and the factors influencing physical activity engagement, ultimately informing the development of effective rehabilitation interventions.

Keywords: HIV, disability, physical activity