Journal of
Physiology and Pathophysiology

  • Abbreviation: J. Physiol. Pathophysiol.
  • Language: English
  • ISSN: 2141-260X
  • DOI: 10.5897/JPAP
  • Start Year: 2010
  • Published Articles: 51

Table of Content: January-June 2022 ; 13(1)

February 2022

Pathophysiological mechanisms of maternal pro-inflammatory mediators in preterm labour

Available therapeutic interventions for managing preterm labour have not been consistently successful due to controversies related to its etiology. Multiple mechanisms, including inflammation play a significant role in the pathogenesis of preterm labour. The connective tissue extracellular matrix of the amniochorion contains collagen fibres that maintain the tensile strength of the amniochorion, resisting mechanical...

Author(s): Kwame Adu-Bonsaffoh, and Fidelis Bayor  

February 2022

Acute toxicity profile of ethanolic extracts of Croton gratissimus Burch and Schrankia leptocarpa DC in rats: Medicinal plants used in the treatment of arterial hypertension in Beninese traditional medicine

Croton gratissimus Burch. and Schrankia leptocarpa DC. are two plants from the Beninese flora which are traditionally used for the treatment of arterial hypertension. The present study investigated the acute toxicity of ethanolic extracts of these plants. The experiment was conducted according to OECD guideline 423 categories 5 using a single dose of 5000mg/kg of the extracts. The average lethal doses (LD50) of the...

Author(s): Koutchiko Angélus Hénok Sègla, Attakpa Sèlidji Eugène, Akotègnon Rodrigue, Guinnin Félix, Sènou Maximin, Amoussa Abdou Madjid, Lagnika Latifou, Sina Haziz, Yédomonhan Hounnankpon, Baba-Moussa Farid, Sezan Alphonse and Baba-Moussa Lamine