Abstract

Trypanosomosis is a major constraint to livestock production in sub Saharan Africa. The distribution of the disease is influenced by the existence of tsetse and biting flies. Tsetse transmitted trypanosomosis is encountered in many part of Ethiopia. Trypanocidal drugs remain the principal method of animal trypanosomosis control in the country. However, there is growing concern that their future effectiveness may be severely reduced by widespread drug resistance. Because it is very unlikely that new trypanosomal drugs will be released on to the market in the future, it is essential to maintain the efficacy of the currently available drugs. So proper detection methods of drug resistance by test in ruminants, in mice, in vitro and molecular tests, and followed by the right techniques on the delay of the development of drug resistance like reduction in the number of treatments, avoidance of under dosage, use of national drug police and if once resistance present allowing integrated control measures such as reducing vector numbers to reduce the number of drug treatments will be of great importance.

Kew words: Africa Ethiopia, Trypanocidal drugs, Trypanosomosis.