Journal of
Parasitology and Vector Biology

  • Abbreviation: J. Parasitol. Vector Biol.
  • Language: English
  • ISSN: 2141-2510
  • DOI: 10.5897/JPVB
  • Start Year: 2009
  • Published Articles: 204

Full Length Research Paper

Effects of treatment with fraction IV extract of Ximenia americana on the survival rate, packed cell volume and total plasma proteins of Trypanosoma congolense infected mice

Beatty Viv Maikai
  • Beatty Viv Maikai
  • Department of Public Health and Preventive Medicine, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria.
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Victor Ambrose Maikai*
  • Victor Ambrose Maikai*
  • Department of Biochemistry, Faculty of Science Kaduna State University, Tafawa Balewa Way, Kaduna, Nigeria.
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  •  Received: 25 February 2015
  •  Accepted: 22 April 2015
  •  Published: 30 June 2015

Abstract

The effect of treatment with fraction IV extract of Ximenia americana on the survival rate, packed cell volume and total plasma proteins of Trypanosoma congolense infected mice was investigated. Following infection with 104 T. congolense, the mice were treated with  25 mg/kg body weight fraction IV extract and 20 mg/kg body weight Diminazene aceturate, respectively, while a group was left untreated. Parasitaemia, packed cell volume, total plasma proteins and survival rate was determined. The results showed fraction IV portion of X. americana significantly (P < 0.05) enhanced the survival rate, packed cell volume of the treated animals, and also reduced the levels of parasite and total plasma proteins compared to the infected untreated groups. Fraction IV portion of X. americana could act as an adjunct therapeutic agent in the treatment of trypanosomosis.

 

Key words: Ximenia americana, Trypanosoma congolense, survival rate, total plasma proteins. 

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This article is published under the terms of the Creative Commons Attribution License 4.0

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