Research in Pharmaceutical Biotechnology

  • Abbreviation: Res. Pharm. Biotech.
  • Language: English
  • ISSN: 2141-2324
  • DOI: 10.5897/RPB
  • Start Year: 2009
  • Published Articles: 42

Full Length Research Paper

Evaluation of the gastrointestinal activity of the aqueous root extracts of Talinum triangulare

Olufunmilayo Adeyemi
  • Olufunmilayo Adeyemi
  • Department of pharmacology, College of Medicine, University of Lagos, Lagos, Nigeria.
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Oluwafunmilade Oyeniyi
  • Oluwafunmilade Oyeniyi
  • Department of pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Akwa Ibom, Nigeria.
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Herbert Mbagwu
  • Herbert Mbagwu
  • Department of pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Akwa Ibom, Nigeria.
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Clement Jackson
  • Clement Jackson
  • Department of pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Akwa Ibom, Nigeria.
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Adeniyi P. A. O.
  • Adeniyi P. A. O.
  • Department of Anatomy, P. M. B 1515, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.
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Musa A. A.
  • Musa A. A.
  • Department of Anatomy, P. M. B 1515, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.
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  • Article Number - EAD607E473
  • Vol.3(6), pp. 61-67, June 2011
  •  Accepted: 24 May 2011
  •  Published: 30 June 2011

Abstract

 

The effect of the aqueous root extract of Talinum triangulare on the gastrointestinal system was evaluated in mice and rats using normal intestinal transit. Castor oil induced diarrhea and castor oil induced enteropooling models. The result obtained showed that, the effects of the aqueous root extract were dose dependent and biphasic in all the models used. The extract (500, 1000 and 2000 mg/kg) produced a significant (p < 0.05) dose dependent decrease in propulsion in normal intestinal transit. The extract at 2000 mg/kg produced a significant (p < 0.05) decrease in the frequency of defecation, severity of diarrhea and, afforded protection from diarrhea in rats treated with castor oil. Unlike atropine, the aqueous extract (500, 1000 and 2000 mg/kg) significantly (p < 0.05) inhibited castor oil induced enteropooling. The extract was found to contain alkaloids, saponins, tannins, combined anthraquinones, cardiac glycosides and phenol when subjected to phytochemical analysis. The extract gave an LD50 of 5514 mg/kg when administered orally and 403 mg/kg when given intraperitoneally.

 

Key words: Talinum triangulare, entropooling, biphasic, LD50, phytochemical analysis.