The effect of the aqueous root extract of Talinum triangulare on the gastrointestinal system was evaluated in mice and rats using normal intestinal transit. Castor oil induced diarrhea and castor oil induced enteropooling models. The result obtained showed that, the effects of the aqueous root extract were dose dependent and biphasic in all the models used. The extract (500, 1000 and 2000 mg/kg) produced a significant (p < 0.05) dose dependent decrease in propulsion in normal intestinal transit. The extract at 2000 mg/kg produced a significant (p < 0.05) decrease in the frequency of defecation, severity of diarrhea and, afforded protection from diarrhea in rats treated with castor oil. Unlike atropine, the aqueous extract (500, 1000 and 2000 mg/kg) significantly (p < 0.05) inhibited castor oil induced enteropooling. The extract was found to contain alkaloids, saponins, tannins, combined anthraquinones, cardiac glycosides and phenol when subjected to phytochemical analysis. The extract gave an LD50 of 5514 mg/kg when administered orally and 403 mg/kg when given intraperitoneally.
Key words: Talinum triangulare, entropooling, biphasic, LD50, phytochemical analysis.
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