Scientific Research and Essays

  • Abbreviation: Sci. Res. Essays
  • Language: English
  • ISSN: 1992-2248
  • DOI: 10.5897/SRE
  • Start Year: 2006
  • Published Articles: 2730

Table of Content: 15 January, 2019; 14(1)

January 2019

Development and execution of a novel strategic statistical tool to determine in-vitro in-vivo correlation for sustained release capsules of metoprolol tartrate in humans

The aim of this present study was to develop and formulate sustained release coated metoprolol tartrate matrix granules and to design an in-vitro in-vivo correlation (IVIVC) tool based on bioavailability data available from human volunteers. USP apparatus II, paddle type was used for generation of in-vitro drug release data for each formulation. The similarity factor (f2) was determined using dissolution data parameters...

Author(s): Sabahuddin Siddique, Mohi Iqbal Mohammed Abdul, Syed Ata Ur Rahman, Durdana Lateef, Anirbandeep Bose, Shubhasis Dan, Faraz  Siddiqui