April 2008
Emphasizing the vitality of genomics related research in the area of infectious diseases
Sequencing of the human and other species genomes has generated a downstream of sciences that have taken advantage of this knowledge to generate vital links between diseases and genetic variants. Sub-Saharan Africa and many developing countries form the major epicenters for Infectious diseases. Here, the role that genomics may hold in the area of infectious diseases research is emphasized in five blocks:...
April 2008
Cytoadherence and pathogenesis of Trichomonas vaginali
Trichomonas vaginalis, a flagellate protozoan parasite is responsible for trichomoniasis, the number one non-virally sexually transmitted disease. Although both men and women are infected, it causes disease almost exclusively in women. There are up to 250 to 350 million new cases oftrichomonad vaginitis annually worldwide. T. vaginalis has the ability to attach to host cells (cytoadherence)...
April 2008
Hepatitis C virus infection in Abidjan Cote d Ivoire: Heterogeneity of genotypes
Whereas the distribution of HCV genotypes in many countries is well documented, very little is known about the genotypes prevalent in Cote d’ Ivoire, in West Africa. This study was undertaken to clarify molecular characteristics of HCV isolated in Cote d’ Ivoire. Plasma samples from 2866 blood donors and 100 patients hospitalized at the teaching hospital of Cocody in Medical and Pediatrics’...
April 2008
Identification of FANCA interacting proteins in mammalian cells using tandem affinity purification and mass spectrometry
Tandem affinity purification (TAP) allows for the isolation of protein complexes under close-to-physiological conditions for subsequent protein identification by mass spectrometry. Although TAP has been successfully applied to yeast system, there are only a few reports in mammalian cells. In this study, the genefanca was cloned into the commercially available TAP construct from Stratagene and transiently...
April 2008
Extracellular enzymes from brown-rot fungus Laetiporus sulphureus isolated from mangrove forests of coastal Tanzania
A brown-rot fungus, Laetiporus sulphureus (Fr.) Murr., was isolated from Mbweni, Oyster Bay and Mtoni Mangroves Forests in Dar es Salaam, Tanzania, and the biochemical properties of its extracellular enzymes were investigated. The crude culture filtrate was concentrated by ultrafiltration. Protein content and lignocellololytic enzyme activities were measured by photometric methods. The crude enzyme...
April 2008
Prevalence of malaria in blood donors in Abakaliki Metropolis, Nigeria
In view of the problem of transfusional malaria, the prevalence of Plasmodium in transfused blood was assessed. Blood film examination for malaria parasites in donor blood transfused to patients in Abakaliki, Ebonyi State of Nigeria was carried out over a 5-month period. Blood group O was the dominant blood type (74%). A high malaria parasite prevalence rate of 51.5% was noted in transfused donor blood. All...
April 2008
Incidence of coracoclavicular joint in adult Nigerian population
Coracoclavicular joint is a diarthrotic synovial joint occasionally present between the conoid tubercle of the clavicle and the superior surface of the horizontal part of the coracoid process. We investigated the prevalence of the coracoclavicular joint using 1637 antero-posterior chest and shoulder radiographs of adults in a Nigerian population, comprising 963 males and 674 females, aged 18 – 88...
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