39th CSN Annual International Conference

Synthesis, characterization and biological activity of new mannich base 1-((4-chlorophenyl)(2,5-dioxopyrrolidin-1-YL) methyl) urea

Abdullahi M. R.
  • Abdullahi M. R.
  • Department of Pure and Industrial Chemistry, Bayero University Kano, P. M. B. 3011, Nigeria
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Rajeswari S.
  • Rajeswari S.
  • 2Department of Chemistry, SRM University, Kattankulathur, Tamil Nadu, India.
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  • Article Number - 1106B56


A new mannich base 1-((4-chlorophenyl)(2,5-dioxopyrrolidin-1-yl)methyl) urea has been synthesized from the condensation of succinimide, 4-chlorobenzaldehyde and urea. The compound has been characterized on the basis of elemental analysis, FTIR, 1HNMR 13C NMR, and Mass spectroscopy. The compound was tested for its antimicrobial activity against Pseudomonas aeruginosa, Staphylococcus aureus, Aspergillus niger  and Candida albicans using agar well diffusion method.


Key  words: Mannich base, succinimide, antimicrobial.