Pyrimidine template is a highly privileged motif for the development of molecules of biological and pharmaceutical interest due to its prebiotic nature to life. This present study deals with the synthesis of pyrimidin- 2(1H)-one derivative from chalcones by the action of silica supported sulfuric acid (SSA) or conventional refluxed in concentrated hydrochloric acid. The chemical structures were confirmed by analytical data and spectroscopic means such as UV, IR, mass spectra, 1H and 13CNMR. SSAwas found to be efficient method for the quantitative transformation to pyrimidine frame work. It can be re-used after simple washing with chloroform thereby rendering this procedure more economical.
Key words: Spectroscopic means, chalcones, pyrimidine, 4-phenylbut-3-en-2-one.
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