African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12488

Full Length Research Paper

Preliminary studies on cytotoxic effect of fungal taxol on cancer cell lines

V. Gangadevi and J. Muthumary*
Centre for Advanced Studies in Botany, University of Madras, Guindy Campus, Chennai – 600 025, Tamil Nadu, India.
Email: [email protected]

  •  Accepted: 19 January 2007
  •  Published: 18 June 2007

Abstract

 

Taxol is an important anticancer drug used widely in the clinical field. Some endophytic fungi were isolated from selected medicinal plants and screened for the production of taxol. The effect of cytotoxicity of fungal taxol isolated from fungal endophytes was investigated by apoptosis method. The presence of taxol in the culture filtrate of endophytic fungi was determined by thin layer chromatography. The fungal taxol isolated from the organic extract of six fungal cultures, had strong cytotoxic activity towards BT 220, H116, Int 407, HL 251 and HLK 210 human cancer cells in vitro.

 

Key words: Endophytic fungi, medicinal plants, taxol, cytotoxic activity, apoptosis.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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