African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12481

Full Length Research Paper

Evaluation of antidiarrhoeal activity of the stem bark of Cylicodiscus gabunensis (mimosaceae)

KOUITCHEU MABEKU Laure B.1*, PENLAP BENG V.2, KOUAM J.3, NGADJUI Bonaventure T.3, FOMUM Z. T.3, ETOA F. X.1 
1Microbiology Laboratory, Department of Biochemistry, Faculty of Science, P. O. Box 812, University of Yaoundé I, Cameroon. 2Toxicology and Pharmacology Laboratory, Department of Biochemistry, Faculty of Science, P. O. Box 812, University of Yaoundé I, Cameroon. 3Phytochemistry Laboratory, Department of Organic Chemistry, Faculty of Science, P. O. Box 812, University of Yaoundé I, Cameroon.
Email: [email protected]

  •  Accepted: 28 March 2006
  •  Published: 02 June 2006

Abstract

The ethyl acetate (EA) extract of the stem bark of Cylicodiscus gabunensis (CG) (Mimosaceae) was analysed for its anti-diarrhoeal activity. Like loperamide (3 mg/Kg body weight), a single oral dose of C. gabunensis ethyl acetate extract (CG-EA) (375, 750 mg/Kg body weight) produced a significant decrease in the severity of diarrhoea. To understand the mechanism of its anti-diarrhoeal activity, its effect was further evaluated on intestinal transit, castor oil induced intestinal fluid accumulation (enteropooling) and electrolyte concentration in the small intestinal fluid. CG-EA produced a decrease in intestinal transit (10.26-30.75%), and unlike atropine, it significantly inhibited castor oil induced enteropooling. However, it did not alter the electrolyte concentration in intestinal fluid as compared to castor oil-treated rats.

 

Key words: Cylicodiscus gabunensis, antidiarrhoeal activity, castor oil.

Copyright © 2024 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

Back to Vol. 5 No. 11
Back to articles
  • Articles on Google by:
SUBSCRIBE TO RSS
SUBMIT MANUSCRIPT
CONFERENCES