African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12481

Full Length Research Paper

In vitro evaluation of the interaction between tea extracts and penicillin G against staphylococcus aureus

Esimone, C. O.1, 3*, Iroha, I. R.1,2, Ibezim, E. C. 1, Okeh, C. O.2 and Okpana, E. M.1
1Department of  Pharmaceutics, University of Nigeria, Nsukka, Nigeria. 2Deparment of Applied  Microbiology, Ebonyi State University, Abakaliki, Nigeria. 3Deparment of Molecular  and Medical Virology, Ruhr University, Bochum, Germany.
Email: [email protected]

  •  Published: 11 May 2006

Abstract

The herb-drug interaction between tea (Carmelia sinensis) extract and penicillin G (Pen G) was investigated against three strains of Staphylococcus aureus using pair combinations in an in vitro decimal assay for additivity test. Results showed that the interactions between penicillin G and tea extracts were mainly additive against the three strains of S. aureus. This suggests that the concomitant administration of tea and Pen G may not impair the antimicrobial activity of Pen G.       

 

Key words: Penicillin G, tea extract, herb-drug interaction.

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