Abstract

Elevation of serum lipids have been implicated to predispose to cardiovascular disorders which includes hypertension, stroke, atherosclerosis etc. Various studies have reported links between supplementation with vitamin B complex and reduction in oxidative stress and inflammatory reactions, two events associated with cardiovascular disorders. Data on possible direct regulation on lipid profile by vitamin B6 is very scanty. This study is therefore designed to assess role of administration of vitamin B6 in regulation of serum lipids such as total cholesterol, phospholipids, triglycerides, and high density lipoprotein cholesterol (HDL-C). Results showed that serum total cholesterol and triglyceride were significantly reduced (p≤0.05) in rats placed on vitamin B₆ supplements compared with control group. Serum phospholipids and high density lipoprotein cholesterol were significantly elevated (p≤0.05) in rats placed on vitamin B₆supplements when compared with control group. The data showed anti-hyperlipideamic effects of vitamin B6 supplementation in rats.

Key words: Pyridoxine, lipids, cardiovascular disorder, supplement.