The beneficial use of medicinal plant among rural communities has been reported over century’s medicinal properties and toxicity of the plant varies depending on the part of the plant taken like leaves, roots, stem and bark as well as geographical distribution, climate change and nature of the soil. This study aimed to assess the acute toxicity of Tanzania Acacia nilotica extracts in mice. The information generated is useful to the scientific community and the tribe which use the plant for medical purposes. Results show that the use of Acacia nilotica has significance gradual increase of body weight at P<0.05 from 20.316 ± 0.045 to 23.316 ± 0.319 in control and from 20.493 ± 0.082 to 24.155 ± 0.260 in treated group while no significance changes of Hemoglobin concentration observed in control and treated groups from 15.3±0.2 to 15.25±0.45 . Neither mortality nor toxicity observable signs noticed in the experimental and control group during First 24 hours and daily at 2000 g/kg body weight (LD50). The use A.nilotica extract has no acute toxicity in mice and show to be potential safe use of the plant as a medicinal herb.

Keywords: Acute toxicity, Acacia nilotica, miceHemoglobin concentration