African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5229

Full Length Research Paper

Seroprevalence of hepatitis C virus in HIV seropositive children in Lagos, Nigeria

Oyefolu, Akeeb Oriowo Bola
  • Oyefolu, Akeeb Oriowo Bola
  • Department of Microbiology, Lagos State University, Ojo P. M. B. 1087, Apapa, Lagos, Lagos State, Nigeria.
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Ashaka, Oluwaseyi Sedowhe
  • Ashaka, Oluwaseyi Sedowhe
  • Department of Medical Microbiology and Parasitology, College of Health Sciences University of Ilorin, Ilorin. Kwara State, Nigeria.
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Anjorin, Abdulazeez Adeyemi
  • Anjorin, Abdulazeez Adeyemi
  • Department of Microbiology, Lagos State University, Ojo P. M. B. 1087, Apapa, Lagos, Lagos State, Nigeria.
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Salu, Olumuyiwa
  • Salu, Olumuyiwa
  • Department of Medical Microbiology and Parasitology, College of Medicine, University of Lagos, Lagos, Lagos State, Nigeria.
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Akinyemi, Kabiru Olusegun
  • Akinyemi, Kabiru Olusegun
  • Department of Microbiology, Lagos State University, Ojo P. M. B. 1087, Apapa, Lagos, Lagos State, Nigeria.
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Omilabu, Sunday
  • Omilabu, Sunday
  • Department of Medical Microbiology and Parasitology, College of Medicine, University of Lagos, Lagos, Lagos State, Nigeria.
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Abidoye, Gbadegesin
  • Abidoye, Gbadegesin
  • Department of Obstetrics and Gynaecology, Lagos State University Teaching Hospital, Ojo, Lagos State, Nigeria.
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  •  Received: 26 August 2015
  •  Accepted: 29 October 2015
  •  Published: 14 January 2016

Abstract

Human immunodeficiency virus (HIV) may influence hepatitis C virus (HCV) disease through immunosuppression. The aim of this study was to determine the sero-prevalence of HCV in HIV sero-positive children in Lagos, Nigeria. 132 blood samples of children aged 1-15 years were collected at the HIV clinics of Lagos University Teaching Hospital (LUTH) and Lagos State University Teaching Hospital (LASUTH). Confirmatory analysis of HIV sero-status was done using enzyme-linked immunosorbent assay (ELISA) kit. All the 132 children recruited were HIV sero-positive. Serological assay for HCV was done on the 132 HIV sero-positive serum samples using ELISA technique. Assay procedures were carried out at the Virology Unit, College of Medicine, University of Lagos. Out of the 132 HIV sero-positive samples, 6 were positive for HCV with a prevalence of 4.54% with sex related prevalence of four (6.58%) males and two (2.82%) females, respectively. Zero prevalence was recorded between age groups 1-3 years while a sero-prevalence of 20% was found among age groups 12-15 years. The result of this study implies that HIV positive children are likely to be co-infected with HCV, thus re-affirming the role of this virus in concomitant HIV associated infection in children which may further complicate their immunocompromised state. 
 
Key words: Human immunodeficiency virus (HIV), hepatitis C virus (HCV), enzyme-linked immunosorbent assay (ELISA), Lagos.
 

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