African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2277

Full Length Research Paper

Development of in vitro-in vivo correlation for pharmacokinetic simulation

Ghulam Murtaza1, Saira Azhar1, Ayisha Khalid2, Bushra Nasir3, Muhammad Ubaid3, Muhammad Khurran Shahzad3, Fatima Saqib3, Iftikhar Afzal2, Sobia Noreen4, Muhammad Tariq5, Tahir Ali Chohan5 and Abdul Malik6
1Department of Pharmaceutical Sciences, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan. 2Department of Pharmacy, University of Balochistan, Quetta 87300, Pakistan. 3Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan. 4Department of Chemistry, University of Sargodha, Sargodha, Pakistan. 5Department of Pharmacy, the University of Lahore, Lahore, Pakistan. 6Faculty of Pharmacy, University of Sargodha, Sargodha, Pakistan.
Email: [email protected]

  •  Accepted: 11 January 2011
  •  Published: 29 January 2012

Abstract

This article presents a comprehensive overview of systematic procedure for establishing and validating an in vitro - in vivo correlation (IVIVC) level A, B, and C. It encompasses all experimental, statistical and mathematical concepts of IVIVC development and its validation. A Level A IVIVC is an important mathematical tool that can help to save time and cost during and after the development of a formulation.

 

Key words: Bioavailability, correlation, dissolution, predictability, Wagner-Nelson equation.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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