African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2277

Short Communication

Investigation of the pharmacokinetics of a novel sustained release metformin hydrochloride suspension with ion exchange resin as carriers in beagle dogs

Hongfei Liu1, Shuang Shuang Shi1, Changshan Sun2*, Xin Zhao3, Sheng Shen1 and Hao He1
1College of Pharmacy, Jiangsu University, Zhenjiang, 212013, China. 2Department of Pharmaceutics, Shen yang Pharmaceutical University, Shen yang 110016, China. 3Teaching affairs office, Jiangsu University, Zhenjiang, 212013, China.
Email: [email protected]

  •  Published: 04 October 2013

Abstract

A novel metformin hydrochloride sustained-release suspension containing ion exchange resin as carriers have been reported in a previous study. In the present study, the pharmacokinetics of this sustained-release suspension in beagle dogs was investigated. A high performance liquid chromatography (HPLC) method was established to detect the amount of metformin hydrochloride in vivo. The pharmacokinetics parameters of the metformin hydrochloride sustained-release suspension and a reference metformin hydrochloride tablet were: AUC0~24(μg·h·ml-1) 72.94 and 78.07, Cmax (μg·ml-1) 7.97 and 15.42, Tmax (h) 4.2 and 1.83 respectively. The results indicated that the suspension was bioequivalent with the reference tablet, and had an obvious sustained-release effect.

 

Keywords: Metformin hydrochloride, sustained-release, ion exchange resin, in vivo, pharmacokinetics.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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