Abstract

The present study is intended primarily to confirm changes with respect to quality of the drug. The variability in proper production unit, supply unit, methodology of collection and storage conditions were used to change the crude herbal drugs. The lack of knowledge of proper methodology, availability and more demands of herbal drugs for better treatment are promoting the practices of adulteration and substitution. Therefore, the standardization of the herbal drugs is essential to the identification of their therapeutic efficacy. Comparative studies were carried out to evaluate the physico-chemical standards of Cassia grandis with emphasis on botanical sensory evaluation, qualitative analysis of the plant’s primary and secondary metabolites, colour produced under ordinary light, ultraviolet-radiation (UV) and thin layer chromatography (TLC) fingerprinting of the drug for chemical identification. Samples were procured from three diverse vicinities to determine the qualitative and quantitative variations. These results indicate the variations in quality and quantity of physicochemical parameters, place and time of collection, analysis procedure, and storage conditions. The study indicates that out of demonstrated samples, self collected sample showed significant results.

Key words: Cassia grandis Linn. leaves, % physico-chemical studies, % standardization.