Abstract

Four hundred - 21 days old male Bovans type chicks in 10 groups were infected with Raillietina tetragona cystcercoids. 6 groups treated with the N-alkyl/COOR derivatives of the open lactam form of praziquantel (PZQ ) in oral dose of 20 mg/kg body weight on day 21 and on day 24 post infection. The open lactam form compounds showed an efficacy of 40, 100, 100, 100, 74 and 56% on the first dose and an efficacy of 50, 100, 100, 100, 100 and 100% respectively on the second dose. Histopathological, haematological and biochemical alterations were evaluated, accordingly no serious signs of toxicity were observed in the birds treated with the different compounds tested.

Key words: PZQ, structure activity relationship, efficacy, toxicity, Raillietina tetragona.