April 2010

Serological evidence for Chlamydia pneumoniae infection following diphtheria-tetanus-pertussis booster vaccination

Increased mortality and morbidity with intracellular pathogens has been reported in females with diphtheria-tetanus-pertussis (DTP) as their most recent vaccination. Within a randomised trial, we investigated the effect of DTP on Chlamydia pneumoniaeserology. Eighteen-month-old children were randomised to DTP booster and oral polio vaccine (OPV) or OPV only. Blood samples collected from 523 children at baseline and...

Author(s): Jane Agergaard, Grethe Lemvik, Ernesto Nante, Marie Helleberg, Jens Nielsen, Christine Stabell Benn, Peter Aaby, and Lars Østergaard

April 2010

The disease progression associated with pirital virus infection in the Syrian golden hamster

Arenaviruses are negative strand RNA viruses that can cause disease and hemorrhagic fever in humans. Typically, research with the hemorrhagic fever causing - arenaviruses requires working in a Biosafety level (BSL)-4 environment which increases the time and cost of testing vaccine and therapeutics. Therefore, we have expanded on the previously described pirital virus (PIRV) animal model for human arenaviral hemorrhagic...

Author(s): Eric M. Vela, Katherine Knostman, Richard Warren, Jennifer Garver and Rachelle Stammen