Abstract

Antibiotic resistance is of grave concern clinically, more so in quinolone-resistant and extended-spectrum beta-lactamase (ESBL)-producing isolates that causes complicated infections. In this study, the potency of Hyptis spicigera leaf extract against some pathogenic microorganisms is described. Minimum bacterial concentration of the leaf extract in five different solvents were tested at five different concentrations (0.625, 1.25, 2.5, 5 and 10 mg/ml). All the solvent extracts showed effective bactericidal potency at 2.5 mg/ml. The phytochemistry of the leaf extracts revealed the presence of tannins, sterols, alkaloids, saponin glycosides and flavonoids. Klebsiella pneumoniae, Neisseria gonorrhae andCandida albicans exhibited the greatest resistance to the bactericidal potency ofH. spicigera leaf extract with high MBC at 5 mg/ml for all the extracts of H. spicigera screened.

Key words: Hyptis spicigera, antimicrobial resistance, Klebsiella pneumoniae,Neisseria gonorrhea, sensitivity, minimum bactericidal concentration.