Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

In vitro antioxidant properties and induced G2/M arrest in HT-29 cells of dichloromethane fraction from Liriodendron tulipifera

Lan Wang1, Gui-Fang Xu2, Xiao-Xia Liu3, Ai-Xia Chang4, Ming-Lu Xu2, Amal Kumar Ghimeray5, Jing-Pei Piao5 and DongHa Cho5*
1College of Life Science, Henan Normal University, Xinxiang, Henan, 453-007, P.R. China. 2Henan Institute of Science and Technology, Xinxiang, Henan, 453-003, P.R. China. 3School of Biology and Chemical Engineering, Jiaxing University, Jiaxing 314001, China. 4Institute of Tobacco, Chinese Academy of Agriculture Science, Qingdao 266000, China. 5Department of Bio-Health Technology, College of Biomedical Science, Kangwon National University, Chuncheon, Gangwon-do, 200-701, Korea.
Email: [email protected]

  •  Accepted: 09 December 2011
  •  Published: 23 January 2012

Abstract

The antioxidant and anti-proliferative effects of dichloromethane fraction from methanol extract of Liriodendron tulipifera were investigated in this study. Scavenging effects on the α,α-diphenyl-picrylhydrazyl (DPPH) and nitrite radicals, and protection against reactive oxygen species induced lipid, protein and deoxyribonucleic acid (DNA) damage were evaluated. The dichloromethane fraction of L. tulipifera exhibited high antioxidant activities to scavenge DPPH and nitrite radicals, ferric reducing power and protection against biological macromolecular oxidative damage. Furthermore, the dichloromethane fraction of L. tulipifera exhibits the anti-proliferative activity and induction of the G2/M arrest in human colon tumor HT-29 cells. These results demonstrate potential antioxidant activities and anti-proliferative effect of L. tulipifera, as an antioxidant for diseases caused by reactive oxygen species.

 

Key words: Free radical, lipid peroxidation, protein oxidation, DNA damage, G2/M arrest.

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