Gastrointestinal nematodes control in sheep has been dominated by use of synthetic anthelminthic. However, the high cost and anthelminthic resistance has stimulated the search for alternative solution as ethno veterinary medicine. This study was conducted in Boloso Sore smallholder farm household, Wolaita Zone, from November, 2018 to April 2019 to evaluate anthelmintic efficacy of combination of Allium sativum, Carica papaya and Curcurbitapeposeed against gastrointestinal nematodes. A purposive sampling was employed to select 48 naturally infected local sheep from source population based on the egg count and age after determining the extent of parasite infection. Randomized complete block design was employed to allocate animals into six groups of which four groups made up of the combinations of Allium sativum, Carica papaya and Curcurbita pepo and the remaining treatments were albendazole and non-treated (water) groups. Fecal samples were collected from each sheep before and after treatment and modified McMaster method was used to count eggs. Third stage larvae (L3) were recovered from the fecal cultures by the Baerman technique. Blood samples were collected from the jugular vein both before and after treatment from each group of sheep to determine the percentage of red blood cells per volume of blood. The efficacy of each preparation was determined by Fecal Egg Count Reduction Test (FECRT) using R Windows software. Means were compared among groups using ANOVA and paired t-tests. The percentage reduction in mean fecal egg count, after 14 days of treatment, for group A, B, C, D, E and F were, 96.2%, 88.84%, 89.8%, 90.36%, 97.01% and 22.8% respectively. There was statistically significant difference among treatment and negative control group (p=0.00). In addition, the baseline mean PCV value before treatment was 30.13 ± 0.743 for group A, 27.61 ± 2.13 for group B, 27.16 ± 1.75 for group C, for group D, 27.7 ±3.4, for group E, 24.23±1.5 and 25.13 ± 2.23 for group F. The finding is within a normal range of 27-45 %. After treatment the PCV value raised slightly for all groups except significant increase for group E. Generally, these findings indicate that the synergetic effect of Garlic, CaricaCarica papaya and Curcurbita are effective against gastrointestinal nematodes in sheep in the study area. Further clinical trials and economic viability should be tested.

Keywords: Cucurbita, Efficacy, Garlic, Carica Carica papaya