Research in Pharmaceutical Biotechnology
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Article Number - 263C215452


Vol.1(1), pp. 009-015 , November 2009

ISSN: 2141-2324


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Full Length Research Paper

Synthesis, antimicrobial potential and toxicological activities of Ni(II) complex of mefloquine hydrochloride



Joshua A. Obaleye
  • Joshua A. Obaleye
  • Department of Chemistry, University of Ilorin, Ilorin, Kwara State, Nigeria.
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Johnson F. Adediji
  • Johnson F. Adediji
  • Department of Chemical Sciences, Ajayi Crowther University Oyo, P. M. B 1066, Oyo, Oyo State, Nigeria.
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Ebenezer T. Olayinka
  • Ebenezer T. Olayinka
  • Department of Chemical Sciences, Ajayi Crowther University Oyo, P. M. B 1066, Oyo, Oyo State, Nigeria.
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Matthew A. Adebayo
  • Matthew A. Adebayo
  • Department of Chemical Sciences, Ajayi Crowther University Oyo, P. M. B 1066, Oyo, Oyo State, Nigeria.
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 Accepted: 24 September 2009  Published: 30 November 2009

Copyright © 2009 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


 

Transition metal complex of Ni(II) with mefloquine hydrochloride (antimalaria drug) was synthesized using a template method. Chemical analysis including conductivity measurements and spectroscopic studies were used to propose the geometry and mode of binding of the ligand to metal ion. From analytical data, the stoichiometry of the complex has been found to be 1:1. Infrared spectral data also suggest that the ligand (mefloquine hydrochloride) behaves as a tridentate ligand with N:N:O donor sequence towards the metal ion. The complex generally showed octahedral coordinate geometry. Molar conductance of 10-2 mol dm-3 methanol solution of the complex indicated non-electrolytic nature of metal complex. It also revealed that the ligand anions were covalently bonded to the complex. In vivoevaluation of antimalarial studies of the metal complex shows greater activities when compared to the free ligand. Mefloquine and its metal complex increased significantly (p < 0.05) serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) and significantly reduced these enzymes in the liver and kidney when compared to the control. This revealed that both mefloquine and its metal complex might show toxicity particularly on the liver and kidney with the metal complex group being mild.

 

Key words: Transition metal, antimicrobial, antimalarial drug, complexation, toxicological studies.


APA (2009). Synthesis, antimicrobial potential and toxicological activities of Ni(II) complex of mefloquine hydrochloride. Research in Pharmaceutical Biotechnology, 1(1), 009-015.
Chicago Joshua A. Obaleye, Johnson F. Adediji, Ebenezer T. Olayinka and Matthew A. Adebayo. "Synthesis, antimicrobial potential and toxicological activities of Ni(II) complex of mefloquine hydrochloride." Research in Pharmaceutical Biotechnology 1, no. 1 (2009): 009-015.
MLA Joshua A. Obaleye, et al. "Synthesis, antimicrobial potential and toxicological activities of Ni(II) complex of mefloquine hydrochloride." Research in Pharmaceutical Biotechnology 1.1 (2009): 009-015.
   
DOI https://doi.org/
URL http://academicjournals.org/journal/RPB/article-abstract/263C215452

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