Abstract

Benign prostate hyperplasia (BPH; n = 63) and prostate cancer (PC; n = 18) patients were ascertained on the basis of prostate specific antigen (PSA) levels from the hospitals located in Tamil Nadu, South India. The patients were analyzed for chromosomal aberrations (CA) using cultured peripheral leucocytes. The patients were grouped into two age group (group I: ≥ 50 yrs; group: II ≤ 51 yrs. Deletions, translocations, inversions and mosaics were the major CA observed in both the groups of chromosome 1, 2, 3 6, 7, 9, 16, 22, and X were the affected chromosome in PC patients and in BPH patients 1, 7 and 16 and Y chromosomes were affected. Chromosomes 1, 7 and 16 were observed in both groups of patients. Group II patients showed higher number of CA than group I. Group comparisons were statistically significant (P<0.001).

Key words: Prostrate cancer patients, benign prostate hyperplasia, chromosomal aberrations, prostate specific antigen, peripheral blood lymphocytes.