African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12392

Full Length Research Paper

Evaluation of the effects of plant aqueous extracts as anti-diabetic agents on alloxan induced diabetic male rabbits

Hadia Akber Samoo
  • Hadia Akber Samoo
  • Institute of Biotechnology and genetic Engineering, University of Sindh, Jamshoro (76080), Sindh, Pakistan.
  • Google Scholar
Jagarwanti Maheshwari
  • Jagarwanti Maheshwari
  • Institute of Biotechnology and genetic Engineering, University of Sindh, Jamshoro (76080), Sindh, Pakistan.
  • Google Scholar
Atta Muhammad Babar
  • Atta Muhammad Babar
  • Institute of Biotechnology and genetic Engineering, University of Sindh, Jamshoro (76080), Sindh, Pakistan.
  • Google Scholar
Ather Hameed Sheikh
  • Ather Hameed Sheikh
  • Institute of Biotechnology and genetic Engineering, University of Sindh, Jamshoro (76080), Sindh, Pakistan.
  • Google Scholar
Imrana Khushk
  • Imrana Khushk
  • Institute of Biotechnology and genetic Engineering, University of Sindh, Jamshoro (76080), Sindh, Pakistan.
  • Google Scholar
Muhammad Aqeel Bhutto
  • Muhammad Aqeel Bhutto
  • Institute of Biotechnology and genetic Engineering, University of Sindh, Jamshoro (76080), Sindh, Pakistan.
  • Google Scholar
Jawaid Ahmad Khokhar
  • Jawaid Ahmad Khokhar
  • Institute of Biotechnology and genetic Engineering, University of Sindh, Jamshoro (76080), Sindh, Pakistan.
  • Google Scholar
Abdul Sattar Qureshi
  • Abdul Sattar Qureshi
  • Institute of Biotechnology and genetic Engineering, University of Sindh, Jamshoro (76080), Sindh, Pakistan.
  • Google Scholar
Syed Akbar Shah
  • Syed Akbar Shah
  • Institute of Biotechnology and genetic Engineering, University of Sindh, Jamshoro (76080), Sindh, Pakistan.
  • Google Scholar
Aftab Hussain Khaskheli
  • Aftab Hussain Khaskheli
  • Institute of Biotechnology and genetic Engineering, University of Sindh, Jamshoro (76080), Sindh, Pakistan.
  • Google Scholar


  •  Received: 28 February 2018
  •  Accepted: 30 July 2018
  •  Published: 05 September 2018

Abstract

This study investigates the effect of barley (Hordeum vulgare), black plum (Syzygium cumini) and Chinese tree leaves (Pistacia chinesis) aqueous extracts  on serum glucose, cholesterol, urea, uric acid level and body weight of normal and alloxan-induced diabetic male rabbits. Rabbits were kept in fasting condition for 12 h, then diabetes was induced using alloxan monohydrate (150 mg/Kg) . From the 7th day of diabetes induction, blood serum was collected for glucose analysis. Rabbits having fasting glucose level ≥ 250 mg/dL were considered as diabetic. Rabbits were treated with 1% barley, black plum and Chinese tree aqueous extract to check their effects on the serum glucose, serum cholesterol, serum urea, uric acid and body weight of the animals. Samples were collected after every 72 h for biochemical analysis. It was noted that 1% barley, black plum and Chinese tree aqueous extract reduced 43.92, 39.05 and 32.47% glucose level. Results suggest that oral administration of aqueous extract of barley, black plum and Chinese tree reduced glucose, cholesterol, urea, and uric acid level. Therefore, these medicinal plants should be supplemented as herbal drugs in the treatment of various complex diseases and specially to control diabetes.
 
Key words: Chinese tree leaves, antidiabetic agents, barley, black plum, rabbits, diabetes mellitus.