African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12487

Full Length Research Paper

Characterization of quinapyramine (Trypacide®) drug-resistant Trypansoma evansi

Intisar E. El Rayah1* and Khitma H. El Malik2    
Trypanosomosis Unit, Tropical Medicine Research Institute (TMRI), P.O.BOX 1304, Khartoum 11111, Sudan. 2Faculty of Veterinary Science, University of Khartoum, P.O Box 32, Khartoum North, Sudan.    
Email: [email protected],[email protected]

  •  Accepted: 30 March 2006
  •  Published: 16 May 2006

Abstract

Molecular karyotyping by pulsed field gel electrophoresis was used to characterizeTrypanosoma evansi isolates. Ten T. evansi isolates from camels were collected in Eastern and Western Sudan. Isolates from Eastern Sudan which were kept under continuous prophylactic treatment with quinapyramine (Trypacide®), were found to bear a single pattern and belonged to one karyotype group. From Western Sudan where trypanosomosis management was done by individual treatment of proven parasitaemic cases, isolates with diverse karyotype patterns were obtained. This study concluded that the occurrence of karyotype homogeneity amongst T. evansiisolates from field situations where anti-trypanosomal compounds have been used may infer the existence of drug-resistance.

 

Key words: Trypanosoma evansi, drug resistance, Trypacide®, karyotyping, Sudan.

 

 

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This article is published under the terms of the Creative Commons Attribution License 4.0

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