African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12487

Full Length Research Paper

The adverse reaction of chitooligosaccharides in rats

  Anjun Liu, Kezhuang Sun1, Chuanling Si2, Zhenyuan Zhu1* and Wei Zhang1  
1Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Science and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, P.R. China. 2Tianjin Key Laboratory of Pulp and Paper, College of Materials Science and Chemical Engineering, Tianjin University of Science and Technology, Tianjin 300457, P.R. China.
Email: [email protected]

  •  Accepted: 07 December 2011
  •  Published: 31 January 2012

Abstract

 

In this study, hair removal effect after subcutaneous injection of chitooligosaccharides in mice was investigated. Different methods of observation of hair removal, tissue slices and detection of hematological parameters, like aminacridone (AMAC) labeled and antagonism treat were employed in this research. It was shown that Chitooligosaccharides exhibited renal toxicity, which was similar to aminoglycoside antibiotics (AmAn) toxicity.

 

Key words: Chitooligosaccharides, adverse reaction, nephrotoxicity, in vivometabolism, antagonism.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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