African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12278

Full Length Research Paper

Application of an antibacterial dressing spray in the prevention of post-operative infection in oral cancer patients: A phase 1 clinical trial

Yizhou Zeng1, Runzhi Deng1*, Barry, H.S. Yeung2, Wings T.Y. Loo3, Mary N.B. Cheung3, J.P. Chen3, Bingrong Zhou1, Yifu Fu1, Lanzhu Huang1, Mingxing Lu1and Min Wang4
  1Department of Oral Maxillofacial Surgery, Nanjing Stomatological Hospital, Nanjing, China. 2Department of Microbiology, Immunology and Molecular Genetics, the University of  California Los Angeles, USA. 3School of Chinese Medicine, the University of Hong Kong, Hong Kong. 4Department of Prosthodontics, West China College of Stomatology, University of Sichuan, Chengdu, P.R. China.
Email: [email protected]

  •  Accepted: 08 October 2008
  •  Published: 05 November 2008

Abstract

 

This study investigates the effects on the prevention of oral infection after operation in oral region by using an antibacterial dressing spray (JUC spray). 60 patients diagnosed with grade 1 and 2 of oral squamous cell cancinoma, and the conservation surgery had applied to them under general anesthesia. Half of these patients were treated with JUC and the rest accepted traditional method. The complete blood picture (CBP) and the growth of bacteria in the wound were analyzed. The average wound healing time in JUC group was significantly shorter than that in the control group. The amount of bacteria presented in wound was lower in JUC group than that in the traditional group. There was no significant difference between the CBP of the two groups. The JUC antibacterial dressing spray, after spraying on the surface of the wound formed a layer of physically antibacterial molecular film to prevent the growth of bacteria and effectively reduced the average wound healing time.

 

Key words: Antibacterial dressing spray, oral squamous cell cancinoma, wound healing, infection.