African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12487

Full Length Research Paper

Biotransformation of ß-estradiol isolated from Sonchus eruca

Javid Hussain1,5*, Zia Muhammad1, Riaz Ullah1,4 , Nargis Jamila3, Shabir Ahmad1, Naeem Khan1, Sultan Ayaz2 and Sajjad Haider4        
1Department of Chemistry, Kohat University of Science and Technology, Kohat-26000, Pakistan. 2Department of Zoology, Kohat University of Science and Technology, Kohat-26000, Pakistan. 3School of Chemical Sciences USM University of Sains Malaysia Penang, Malaysia. 4Department of Chemical Engineering, College of Engineering, King Saud University, P.O BOX 800, Riyadh 11421, KSA. 5Department of Biological Sciences and Chemistry, College of Arts and Sciences University of Nizwa, Oman.
Email: [email protected], [email protected]

  •  Accepted: 25 March 2011
  •  Published: 20 June 2011

Abstract

The biotransformation of ß-estradiol (1,3,5-estratriene-3,17,ß-diols) by Bacillussubtillus resulted in four metabolites which were (1) 3,5-estratriene-3-ol–17–one, (2) 1,3,5-estratriene-3,16,17-triol, (3) 1,3,5,7-estratetra-ene-3-ol-17-one and (4) 1,3,5,6, estratetra-ene-3-ol-17-one. The structures were elucidated on the basis of spectroscopic techniques. Compound 3 showed good inhibitory activity against lipoxygenase enzyme.

 

Key words: Microbial transformation, ß-estradiol (1,3,5-estratriene-3,17,ß-diols),Bacillus subtillus, Aspergillus niger, lipoxygenase.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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