African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12487

Short Communication

Evaluation of micronutrients level and antinociceptive property of Eremostachys laciniata (L) Bunge

  Salimullah Khan1,2*, Muhammad Nisar2,3, Shabana Usman Simjee4, Wajid Rehman5, Razaullah Khan6, Irfanullah Jan7 and Dure-Shahwar Momin4  
  1Department of Pharmacy, Hazara University Havelian, Abbottabad -22010, Pakistan. 2Department of Pharmacy, University of Peshawar, Peshawar,-25120, Pakistan. 3Institute of Chemical Sciences, University of Peshawar, Peshawar-25120, Pakistan. 4HEJ International Center for Chemical and Biological Studies, Karachi University, Karachi-75270, Pakistan. 5Department of Chemistry, Hazara University, Mansehra-21300, Pakistan. 6Fertiliser and Lime Research Center, Massey University, Palmerston North-11222, New Zealand. 7NCE Geology, University of Peshawar, Peshawar-25120, Pakistan.  
Email: [email protected]

  •  Accepted: 20 November 2009
  •  Published: 01 February 2010

Abstract

 

Eremostachys laciniata (Lamiaceae) a rich source of structurally different flavonoids is ignored for its micronutrients level and many biological activities. In this study, the plant was investigated for different micronutrients including, phosphorus (P), nitrogen (N), boron (B), zinc (Zn) and manganese (Mn) and compared with adequate level of micronutrients for orchid crops. The crude methanol extract and different fractions of E. laciniata were also investigated for in vivo antinociceptive activity using Tail-flick model. Except for boron, all other micronutrients investigated were well in the limits recommended for orchid crops. Crude extract and different fraction thereof showed excellent increase in latency time along with certain central effect of causing sedation, ataxia and hind limb extension. This increase in latency time is not only due to analgesia but may be a combined effect of sedation, ataxia and analgesia. The plant may be a useful source in future for the isolation of natural product with analgesic property. 

 

Key words: Extract, fractions, nitrogen, orchid, analgesic