African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12309

Full Length Research Paper

MiR-124 involvement of apoptosis, immunity and regulator of diseases

Hong-Yan Sun
  • Hong-Yan Sun
  • Joint Laboratory of Guangdong Province and Hong Kong Regions on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural University, Guangzhou 510642, Guangdong Province, PR China.
  • Google Scholar
You-Hua Huang
  • You-Hua Huang
  • Joint Laboratory of Guangdong Province and Hong Kong Regions on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural University, Guangzhou 510642, Guangdong Province, PR China.
  • Google Scholar
Zong-He Yu
  • Zong-He Yu
  • Joint Laboratory of Guangdong Province and Hong Kong Regions on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural University, Guangzhou 510642, Guangdong Province, PR China.
  • Google Scholar
Qi-Wei Qin
  • Qi-Wei Qin
  • Joint Laboratory of Guangdong Province and Hong Kong Regions on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural University, Guangzhou 510642, Guangdong Province, PR China.
  • Google Scholar


  •  Received: 31 December 2019
  •  Accepted: 07 February 2020
  •  Published: 31 March 2020

Abstract

Most microRNAs (miRNAs) are noncoding, conserved RNA molecules in vertebrates, and their roles are similar and very important. MiRNAs usually have tissue-specific expression, and abnormal levels of miRNAs have been associated with diseases and have been used as disease biomarkers. MiRNAs are widely involved in biological processes by regulating target mRNAs. MiR-124 is one of the best studied miRNAs in organisms. By targeting different mRNAs, miR-124 plays important roles in the central nervous system, cellular infiltration, pathophysiological processes of cardiovascular diseases, inflammation, immunity and tolerance, etc. This review mainly focuses on tissue-specific or abnormal expression of miR-124 as a biomarker and on the ways miR-124 for the treatment of serious diseases such as cancers.

 

Key words: miR-124, apoptosis, immune responses, diseases.