Abstract

In recent years, nano lab-on-chip (NLOC) has emerged as a powerful tool for biosensing and an active area of research particularly in DNA genetic and genetic related investigations. Compared with conventional sensing techniques, distinctive advantages of using NLOC for biomedicine and other related area include ultra-high sensitivity, higher throughput, in-situ monitoring and lower cost. This review aims to summarize recent advancements in two major types of NLOC sensing approaches, label and labelled free NLOC, as well as their biomedical applications. The state-of-the-art on how these sensors interface with nano/microfluidics is then presented and the latest papers in the area summarized and also proposal to develop compact NLOC with four different sensing elements with two different mechanisms, common and separate padding is prospected.

Key words: Nano lab-on-chip, in-situ, nano/microfluidics, sensors, DNA.