African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12487

Full Length Research Paper

In vitro cytotoxicity of crude alkaloidal extracts of South African Menispermaceae against three cancer cell lines

  H. De Wet1*, G. Fouche2 and F. R. Van Heerden3  
  1Department of Botany, University of Zululand, Private Bag X1001, KwaDlangezwa, 3886, South Africa. 2Bioprospecting, Biosciences, CSIR, P. O. Box 395, Pretoria, 0001, South Africa. 3School of Chemistry (Pietermaritzburg), University of KwaZulu-Natal, Private Bag X01, Scottsville 3209, South Africa.
Email: [email protected]

  •  Accepted: 05 May 2009
  •  Published: 20 July 2009

Abstract

 

The cytotoxicity of crude alkaloid extracts obtained from the leaves and rhizomes of all the South African members of the family Menispermaceae (seven genera and 13 species) was tested against MCF7 (breast), UACC62 (melanoma) and TK10 (renal) cancer cell lines. Extracts of ten of the thirteen species showed positive activity against all three cancer cell lines with significant inhibition of cellular growth at TGI(total growth inhibition) values lower than 6.25 μg/ml for Albertisia delagoensis andAntizoma angustifolia leaves.

 

Key words: Cytotoxicity, alkaloids, menispermaceae, South Africa.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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