Abstract

In vivo clinical trials involving oral daily administration of crude aqueous extracts ofcissus populnea to grouped sprague-dawley rabbits at two dose levels of 200 and 600 gkg^-1 body weight over a 60 day study period revealed that continuous exposure of the plant extract had no damaging effects on the organs of xenobiotic metabolism (liver and kidney). results of levels of serum ast, alt, alkaline phosphatase, creatinine, bilirubin and triglycerides of the two groups were not significantly different (p £ 0.05) at the end of the study from those of the control group.

Key words: Cissus populnea, liver and kidney function, rabbits.