Abstract

The aim of this study is to evaluate the liver’s protection of Ananas comosus on albinos Wistar rats intoxicated with Doliprane® which contained 20% of paracetamol. Four batches of 30 were used. The negative control group was not treated with Doliprane® and A. comosus. Batches no. 2 and no. 3 were treated for six weeks with Doliprane® (2 g per kg of body weight for each day). Each rat of batch 2, has received by cramming, 0.06 ml/kg of body weight for each day of the stalk against 0.12 ml per kg of body weight for each day for batch no. 3. The batch no. 4 has been addicted to Doliprane® (2 g / kg of body weight for each day) and was not treated with A. comosus. A haematological study plus determination of the serum level of glucose, triglycerides and cholesterol was carried out. Doliprane® induced a hypochromic anemia in the rats of batch 4. This anemia has been corrected with the stalk of A. comosus in the rats of batches no. 2 and no. 3. The serum level of glucose and triglycerides increased in the rats of batch no. 4 (p < 0.0001), but that of cholesterol decreased (p < 0.0001). The stalk of A. comosus protects the liver against haematological and biochemical aberrations induced by Doliprane®.

Key words: Ananas comosus (pineapple), hepato-protection, Doliprane®, toxicity.

Abbreviation

MCV, mean blood volume; LD₅₀, half maximal lethal dose; ATP,adenosine triphosphate; TGMH, mean corpuscular hemoglobin.