Abstract

The aim of this study is to determine the effects of combined application of testosterone and nandrolone on male rabbits during adolescence period for biochemical values which are indicators of damage to heart, liver and kidney. Seven male New Zealand white rabbits, 60-days old, were used in this study. Testosterone (10 mg/kg) + nandrolone deconoate (10 mg/kg) were injected simultaneously to the rabbits in an intramuscular manner once in 1 week for a period of 12 weeks. Blood samples were taken in 0, 4, 8 and 12 weeks. Serum creatine kinase-MB, lactate dehydrogenase, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl-transferase, creatinine and blood urea nitrogen were measured with an auto-analyzer. Combined use of testosterone and nandrolone caused (p < 0.05) increase in serum creatine kinase-MB activity, but no statistical changes (p > 0.05) were determined in other parameters. As a result, it can be concluded that the use of testosterone plus nandrolone simultaneously during early ages may cause heart damage.

Key words: Testosterone, nandrolone, creatine kinase-MB.

Abbreviation

Abbreviations: AIDS, Acquired immune deficiency syndrome; AAS, anabolic androgenic steroids; WADA, world anti doping agency; CK-MB, creatine kinase-MB;LDH, lactate dehydrogenase; ALP, alkaline phosphates; ALT, alkaline aminotransferase; AST, aspartate aminotransferase; GGT, gamma glutamyl transferase; BUN, urea.