Abstract

A total of 40 experimental rats (Rattus norvegicus) were divided into three groups: 10 rats for G1 (normal rats), 15 rats for G2 [rats that were exposed to aramite with daily intake of food for 90 days (5 g aramite/1 kg of pellet diet)] and 15 rats for G3 [rats that were exposed to aramite with daily intake of water for 90 days (5 g aramite dissolved in 1 L tap water)]. The result showed that the rats treated with aramite had significant increase in the activity and level of glutamate pyruvate transaminase (GPT), glutamate oxaloaceate transaminase (GOT), acid phosphatase activity (ACP) and alkaline phosphatase activity (ALP) (P≤0.05) when compared with the control group. The results indicated histopathological changes in the liver and intestine with clear mutation in GSTM1 gene in rats that were exposed to aramite with diet and water when compared with the normal control rats.

Key words: Aramite, metabolic gene polymorphism, histopathological, GSTM1.