African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12496

Short Communication

Antisecretory and analgesic activities of Terminalia bellerica

Arif-ullah Khan1,2 and Anwarul Hassan Gilani1*
  1Natural Product Research Division, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi-74800, Pakistan. 2Institute of Pharmaceutical Sciences, Kohat University of Science and Technology, Kohat-26000, Pakistan. 3King Saud University, Riyadh, Saudi Arabia.
Email: [email protected]

  •  Accepted: 17 April 2009
  •  Published: 03 May 2010

Abstract

 

This study describes the antisecretory and analgesic activities of the crude extract of Terminalia bellerica (Tb.Cr). T. bellerica extract inhibited the castor oil-induced intestinal fluid secretion in mice at the dose range of 300 - 1000 mg/kg. The extract also dose-dependently (50 - 100 mg/kg) reduced the numbers of acetic acid-mediated writhes in mice. These results indicate that T. bellerica exhibit antisecretory and anti-nociceptive effects, hence justifying its medicinal use in diarrhea and pain.

 

Key words: Terminalia bellerica, intestinal secretion, analgesia.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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