African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12481

Full Length Research Paper

Protein modeling of apical membrane antigen-1(AMA-1) of Plasmodium cynomolgi

D.M. Mamatha¹*, K. Nagalakshmamma1, V.A. Dev Rajesh2 and V.S. Sheerin3
¹Department Sericulture and Biosciences Sri Padmavathi women’s University, Tirupati, A.P, India. 517502. 2Department of Bioinformatics, Dravidan University, Kuppam, A.P., India. 3Department of Biosciences Sri Padmavathi women’s University, Tirupati, A.P, India. 517502.
Email: [email protected]

  •  Accepted: 26 October 2007
  •  Published: 19 November 2007

Abstract

Apical membrane Antigen-1(AMA-1), an asexual blood stage antigen of Plasmodium cynomolgi, is an important candidate for testing as a component of malarial vaccine. The degree of conservation of AMA-1 sequences implies a conserved function for this molecule across different species of Plasmodium. Since the AMA-1 of plasmodium cyanomolgi is yet to be structured, the authors have generated a homology model of AMA-1 by using the Swiss-PDB server. The protein’s conservity has been verified by performing multiple alignments using Bioedit and conserved domain database. The model was further checked for its correctness by predicting 2D and 3D structures, which validates the structure.

 

Key words: Protein model, AMA-1, apical membrane antigen-1, Plasmodium cynomolgi.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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