Anatomical and powdered samples of stem bark of Daniellia oliveri were investigated for its micromorphological profile, while the aqueous extract was investigated for its anti-nociceptive and anti-inflammatory effects in mice and rats, respectively. The micromorphological study indicated the presence of characteristic bundles of phloem tissues, separated by medullary rays, abundant grains of starch in isodiametric parenchyma cells, prisms of calcium oxalate crystals, cork cells and cortex parenchyma. The extract showed a significant anti-nociceptive activity at the tested doses (50, 100, 200 mg/kg i.p.). The extract at the same doses showed a non-dose dependent anti-inflammatory activity. The effect was significant at doses of 100 and 200 mg/kg. These findings contribute to the preparation of a monograph for proper identification of the plant and also corroborate some of the traditional uses.

Key words: Acute toxicity, anti-inflammation, anti-nociceptive, chemomicroscopy,Daniellia oliveri, micromorphology, phytochemical screening.