African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12227

Full Length Research Paper

The bioactive and phytochemical properties of Garcinia kola (Heckel) seed extract on some pathogens

Adegboye, M. F.1, Akinpelu, D. A. 1,2* and Okoh, A. I.2   
  1Department of Microbiology, Obafemi Awolowo University, Ile Ife, Nigeria. 2Applied and Environmental Microbiology Research Group (AEMREG), Department of Biochemistry and Microbiology, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa.
Email: [email protected]

  •  Accepted: 29 August 2008
  •  Published: 05 November 2008

Abstract

 

In vitro antimicrobial activities of crude extract of Garcinia kola was investigated against some bacterial isolates comprising of both Gram-positive and Gram-negative organisms. The methanolic crude extract exhibited significant inhibitory action against eleven out of fifteen bacterial isolates tested at a final concentration of 20 mg/ml. The zones of inhibition exhibited by the extract against the tested organisms ranged between 10 and 23 mm, while the zones of inhibition exhibited by streptomycin and tetracycline used as standard antibiotics ranged between 15 and 25 mm; 12 and 25 mm respectively. On the other hand, the minimum inhibitory concentrations exerted by the extract against the bacterial isolates ranged between 0.079 and 5.00 mg/ml while the ranged exhibited by streptomycin was between 0.0157 and 0.50 mg/ml. The plant extract compared favourably with the two standard antibiotics used in this study. The following phytochemical compounds were present in the plant extract: flavonoids, tannins, cardiac glycoside, saponins, steroids and reducing sugars.

 

Key words: Garcinia kola, antimicrobial activity, minimum inhibitory concentrations, phytochemical compounds.